Endocrine Abstracts

Background: Serotonin produced by ileum neuroendocrine tumors (i-NETs) promotes development of the mesenteric mass (MM) associated with lymph node metastases. We previously reported that more extensive MM progression along the superior mesenteric vessels predicts a lower rate of complete surgical resection. In this study, we hypothesized that tumoral serotonin production is associated not only with the development of MM but also its progression, and we examined serotonin level...

Background: Serotonin production by ileum neuroendocrine tumors (i-NETs) is considered a critical mediator of the fibrotic reaction in mesenteric mass (MM)/ lymph node metastasis. Antidepressants modify serotonin dynamics: however, their role in MM formation is uncertain. We hypothesized that histories of antidepressant use affect MM formation. This study examined the correlation between antidepressant use and MM formation.Methods: One hundred eighty-two...